Medscape

Targeting an Autocrine Loop in Small-cell Lung Cancer: Irrelevant Target or Ineffective Drug?

The functional autocrine loop constituted by coexpression of the KIT receptor tyrosine kinase (TK) and its ligand stem cell factor was first reported in small-cell lung cancer (SCLC) tumors and cell ...
Nature

An autocrine inflammatory forward-feedback loop after chemotherapy withdrawal facilitates the repopulation of drug-resistant breast cancer cells

To determine whether autocrine mechanisms are implicated in the tumor microenvironment after intermittent exposure to chemotherapeutic drugs and enhance breast CSC phenotypes, we treated breast cancer ...
Nature

Blocking the autocrine regulatory loop of Gankyrin/STAT3/CCL24/CCR3 impairs the progression and pazopanib resistance of clear cell renal cell carcinoma

The poor prognosis of clear-cell renal cell carcinoma (ccRCC) patients is due to progression and targeted drug resistance, but the underlying molecular mechanisms need further elucidation. This study ...
EurekAlert!

IL-17 Autocrine Loop (IMAGE)

After activation through its T-cell receptor, Th17 cells produce IL-17A, which binds to its own receptor on the Th17 cell. This activates the NFκB pathway. NFκB drives production of IL-24, which in ...