Tuberculosis is the world's leading infectious cause of death, killing more than one million people each year. When the antibiotic bedaquiline was introduced in 2012, it was the first new tuberculosis ...

This "tripartite" protein complex, also known as a multidrug efflux pump, forms a conduit that drains out not only antibiotics but also virulence factors -- i.e., molecules that are produced by the ...

University of Colorado has divulged efflux pump (bacterial) inhibitors reported to be useful for the treatment of bacterial infections, particularly, gram-negative bacterial infections.

Researchers headed by a team at King’s College London have developed a new way of designing antibiotics that could support the discovery of new treatments for drug-resistant infections. Designed to ...

A new way of designing antibiotics could support the discovery of new treatments for drug-resistant infections. It could also help revive antibiotics that have lost effectiveness because bacteria have ...

AMES, Iowa – Research teams led by Edward Yu of Iowa State University and the Ames Laboratory have described the structures of two proteins they believe pump antibiotics from bacteria, allowing the ...

Scientists at Fujifilm Corp. and Osaka University have described piperazine derivatives acting as drug efflux pump inhibitors reported to be useful for the treatment of bacterial infections.

A Cornell University-led collaboration has uncovered the equipment that enables bacteria to survive exposure to antibiotics: a shuttling mechanism that helps a complex of proteins pump out a wide ...