Sterol regulatory element-binding proteins (SREBPs) play a crucial role in lipid biosynthesis. In a recent study, researchers identified a novel cleavage enzyme of SREBP-1c, a key player in fatty acid ...

Lipoxygenases constitute a family of non-heme iron or manganese-dependent enzymes that catalyse the regio- and stereospecific dioxygenation of polyunsaturated fatty acids (PUFAs) to yield hydroperoxy ...

Lipids are a diverse group of hydrophobic or amphipathic biomolecules that serve as structural components of cell membranes, energy stores and signalling mediators. Major classes include fatty acids, ...

Ectopic lipid accumulation in skeletal muscle is a major health concern driven by factors like high-fat diets, lack of ...

Scientists at UC Irvine have found a way to potentially reverse age-related vision loss by targeting the ELOVL2 “aging gene” and restoring vital fatty acids in the retina. Their experiments in mice ...

While C13 fatty acid remains elusive in human plasma, new findings reveal its microbial origins, unique metabolic pathways, and potential as a biomarker for understanding how diet and the gut ...

A noticeable deficit of highly unsaturated lipids — including omega-3 fatty acids — found in women with Alzheimer's disease (AD) but not in cognitively healthy women is linked to worse cognition and ...

In pre-clinical models, high levels of lipids accelerated tumor growth in triple-negative breast cancer cells. Targeting blood lipids through medication or diet may help slow cancer progression, ...

Messenger ribonucleic acid (mRNA)-based therapeutics and the potential of mRNA as a treatment for various conditions has been researched for decades. A key challenge remains finding a delivery system ...

Cosmetics have been used since early civilization, and products were obtained from natural compounds including flowers, milk, seeds, fruits, and vegetables, alongside minerals. Cosmetic products are ...

Researchers have been studying the transcription factor, SREBP, a critical regulator of lipid biosynthesis. Precursor SREBP proteins, located in the endoplasmic reticulum (ER) of the cell, are ...