How cells 'back up' DNA replication to survive severe damage

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by ...

One missing metabolic step can turn cancer's DNA-copying machinery into a lethal weakness

Loss of an enzyme necessary for a process called lipoylation disrupts the way cancer cells copy their DNA, increasing their ...
Health And Pharma

Targeting RNase H2 Exposes a New Therapeutic Vulnerability in Triple-Negative Breast Cancer

Researchers at MD Anderson have identified RNase H2 as a key survival mechanism in triple-negative breast cancer, helping ...
ucdavis.edu

Computational Model Uses Language Theory to Predict DNA Shapes That Underlie Gene Expression and Disease

R-loops are structures that form when a strand of RNA (red) forms a stable structure with double-stranded DNA, causing one strand of the DNA to form a loop. R-loops are associated with gene ...
Kaleido Scope

New model for replication of BKPyV virus, a major cause of kidney transplant failure

To better understand BKPyV replication and ways to prevent it, researchers in the UAB Department of Microbiology have published a single-cell analysis of BKPyV infection in primary kidney cells. Their ...
Medical Xpress

Comparing DNA language models to guide optimal AI selection for genomics

Researchers at The University of Texas MD Anderson Cancer Center have performed a comprehensive evaluation of five artificial intelligence (AI) models trained on genomic sequences, known as DNA ...