Nature

Leaky recombinant expression reveals design constraints of bicistronic synthetic operons in Escherichia coli

Protein expression in Escherichia coli is one of the most important applications in biotechnology. Many strains and expression systems are available, and a lot is known about gene regulatory networks ...
Nature

Computational design of allulose-responsive biosensor toolbox for auto-inducible protein expression and CRISPRi mediated dynamic metabolic regulation

Biosensors based on transcription factors (TFs) have shown extensive applications in synthetic biology. Due to the complex multi-domain structure of effector-TF-DNA, computational design of TFs ...
GEN

ExpressionEdits Partners with Boehringer to Enhance Gene Therapies with AI-Based Intron Design

While working on a COVID-19-related project during the lockdown, Kärt Tomberg, PhD, found herself thinking about introns. She was part of a team working on the spike protein used in vaccines. Her task ...
GEN

Codon Optimization Isn’t Equal: Benchmarking Gene Design for Antibody Expression

Justin Byers is the founder and CEO of Axio BioPharma. He holds a BS in biochemistry and molecular biology from Illinois State University and has held leadership roles at Illumina, Danaher, and ...
Business Wire

ExpressionEdits Raises $13M in Seed Funding to Advance Protein Expression Using AI-Driven Intronization Technology

CAMBRIDGE, England--(BUSINESS WIRE)--ExpressionEdits, a biotechnology company optimizing protein expression using AI and proprietary intronization technology, announced today a $13 million seed ...