Classical proteolysis targeting chimeras (Protacs) bind specific targets and E3 ubiquitin-ligases, promoting ubiquitination and degradation of targets by the proteasome. Multiple chimeras that degrade ...
In the world of protein degradation, sometimes a spanner in the works isn’t an inconvenience but the desired result. Paris-based Enodia Therapeutics has launched out of France’s Pasteur Institute and ...
N-terminal acetylation constitutes one of the most prevalent modifications in eukaryotic cells, yet its global influence on protein turnover has only recently become clear. By capping the α-amino ...
Autophagy and lysosomal pathways orchestrate unconventional secretion of Parkinson's disease protein
Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...
Like any complex system, the cell depends on a tightly regulated quality control network to maintain order and prevent the accumulation of harmful proteins. This network governs protein homeostasis, ...
A preclinical study has developed a strategy that enables the forced elimination of proteins that help tumors survive chemotherapy. This finding opens a new avenue to tackle resistance to cancer ...
Targeted protein degradation is changing how drug discovery teams think about disease biology. For many years, small molecule programs were built around inhibition. A compound was expected to bind a ...
By combining CRISPR knock-in with small peptide tags, researchers can study proteins in their native cellular context, ...
In neurodegenerative diseases such as Alzheimer's or Parkinson's, proteins accumulate in the body's cells, fold incorrectly and clump together to form larger aggregates. Normally, cells are able to ...
An idealCRO for protein degradation combines discovery biology, medicinal chemistry, drug metabolism and pharmacokinetics (DMPK), and development expertise within an integrated platform. WuXi AppTec ...
Autophagy and lysosomal pathways orchestrate unconventional secretion of Parkinson’s disease protein
Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...
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