A new RNA search engine can scan millions of cells in seconds for mutations, pathogens, isoforms and other biological clues.

Understand the stages of a standard RNA-seq bioinformatics workflow, including the role of QC, alignment, gene expression quantification, and specialized application analyses Identify key QC metrics ...

To get more out of RNA-seq analysis, scientists at St. Jude Children's Research Hospital created ReDeconv, an algorithmic tool that accounts for transcriptome size differences to unmask those ...

RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at ...

This article and associated images are based on a poster originally authored by Marisa Amato and presented at ELRIG Drug Discovery 2025 in affiliation with Singleron Biotechnologies GmbH. This poster ...

Of the 2,310 tumors submitted for analysis, 110 (4.8%) failed quality control, primarily due to insufficient RNA. Among samples meeting quality thresholds, sequencing was successful in 99.6%.

A complete guide to next-generation sequencing: the chemistry behind major platforms, how libraries are built, data analyzed, ...

Plasma cell-free RNA (cfRNA) is a promising source of non-invasive biomarkers, but its clinical translation is hindered by technical challenges and a lack of protocol standardization, which ...

Researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have documented their use of a new RNA sequencing technology to uncover molecular ...

Outcomes of young-onset colorectal cancer vs late-onset colorectal cancer patients on phase 1 matched and non-matched therapies. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I.