Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to ...

Mice and newts were applied to the one-step Cre-loxP organism creation technology by TAx9. In this study, the researchers succeeded in synthesizing a Cre-loxP integrated vector by placing a short DNA ...

Scientists usually study the molecular machinery that controls gene expression from the perspective of a linear, ...

Gene and cell therapy is moving fast – and in a clear direction. Programs are pushing toward more complex payloads, virus-free engineering, and manufacturing models that can scale from early research ...

Researchers have identified a distinct and reproducible gene expression program associated with neurotransmission in the living human brain, offering unprecedented insight into the molecular ...

Researchers have found statistically significant links between a gene tied to schizophrenia risk and poorer cognitive ...

A synthetic PAS (red) is inserted in the 5′ UTR of a transgene. Without ligand, the cleavage destroys the coding region of the mRNA, therefore, losing transgene expression. Ligand binding to the ...