The collision involving a grey Audi A4 and a white Scania HGV happened near Dunkeld at about 06:00 on Friday.
Drivers are being warned of long delays on the A1 due to a incident involving two lorries.
Two people are in a life-threatening condition after the collision on the M18, police say.
Police say the man, in his 40s, was the driver of a car which collided with a parked lorry.
Irish Mirror on MSN
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