A protein long studied for its role in amyotrophic lateral sclerosis and frontotemporal dementia now appears to serve a ...
Cas9, Transcription Activator-Like Effector Nucleases (TALENs), and Zinc-Finger nucleases (ZFNs) have demonstrated great utility, primarily for genetic knock-out applications, none have been adopted ...
During meiosis, cells must accurately find matching DNA sequences to repair breaks. How this “homology search” works has been unclear. Using optical tweezers-based single-molecule imaging, we show ...
When a woman becomes pregnant, the outcome of that pregnancy depends on many things - including a crucial event that happened while she was still growing inside her own mother's womb. It depends on ...
Natural transformation is a process in which bacteria uptake exogenous DNA from the environment during a transient physiological state called competence. The DNA can either autonomously replicate or ...
Illustration showing how autophagy induction increases the efficiency of precise gene editing. In normal cells, DNA breaks caused by CRISPR–Cas9 are frequently repaired through non-homologous end ...